{"id":91,"date":"2024-07-25T12:51:54","date_gmt":"2024-07-25T03:51:54","guid":{"rendered":"http:\/\/www.sanyofine.co.jp\/?page_id=91"},"modified":"2024-09-18T14:31:32","modified_gmt":"2024-09-18T05:31:32","slug":"vhh","status":"publish","type":"page","link":"http:\/\/www.sanyofine.co.jp\/en\/field\/bio-chemical\/vhh\/","title":{"rendered":"VHH Antibodies"},"content":{"rendered":"\r\n            <main class=\"l-main p-sub p-field p-vhh eng\">\r\n                <div class=\"c-bg js-parallax--sub js-animeElementpageHead isOn-\"><\/div>\r\n\r\n                <div class=\"c-topicPath\">\r\n                    <div class=\"inner\" style=\"overflow-x:hidden;\">\r\n                        <ol class=\"list\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/BreadcrumbList\">\r\n                            <li itemprop=\"itemListElement\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/ListItem\">\r\n                                <a href=\"\/en\/\" itemprop=\"item\"><span itemprop=\"name\">HOME<\/span><\/a>\r\n                                <meta itemprop=\"position\" content=\"1\">\r\n                            <\/li>\r\n                            <li itemprop=\"itemListElement\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/ListItem\">\r\n                                <a href=\"\/en\/field\/\" itemprop=\"item\"><span itemprop=\"name\">The Business\r\n                                        Fields<\/span><\/a>\r\n                                <meta itemprop=\"position\" content=\"2\">\r\n                            <\/li>\r\n                            <li itemprop=\"itemListElement\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/ListItem\">\r\n                                <a href=\"\/en\/field\/bio-chemical\/\" itemprop=\"item\"><span\r\n                                        itemprop=\"name\">Biochemistry<\/span><\/a>\r\n                                <meta itemprop=\"position\" content=\"3\">\r\n                            <\/li>\r\n                            <li itemprop=\"itemListElement\" itemscope=\"\" itemtype=\"http:\/\/schema.org\/ListItem\">\r\n                                <a href=\"\/en\/field\/bio-chemical\/VHH\/\" itemprop=\"item\"><span itemprop=\"name\">VHH\r\n                                        Antibodies<\/span><\/a>\r\n                                <meta itemprop=\"position\" content=\"4\">\r\n                            <\/li>\r\n                        <\/ol>\r\n                    <\/div>\r\n                <\/div>\r\n\r\n\r\n\r\n                <div class=\"inner\">\r\n                    <h1 class=\"c-title -left\">\r\n                        <span class=\"head\">VHH Antibodies<\/span>\r\n                    <\/h1>\r\n                <\/div>\r\n\r\n                <ul class=\"c-flex -spB c-listNav_anchor p-anchor01\">\r\n                    <li>\r\n                        <a href=\"#anchor1\" class=\"c-btn -arrow_bottom\">VHH Antibody Contract Services<\/a>\r\n                    <\/li>\r\n                    <li>\r\n                        <a href=\"#anchor2\" class=\"c-btn -arrow_bottom\">Sales of VHH Antibody Samples<\/a>\r\n                    <\/li>\r\n\r\n                    <!-- \r\n                    <li>\r\n                        <a href=\"#anchor3\" class=\"c-btn -arrow_bottom\">Leaflet<\/a>\r\n                    <\/li>\r\n                    -->\r\n\r\n                <\/ul>\r\n\r\n                <div class=\"c-section c-beforeBgColor\"> <!-- \u30ca\u30d3\u30b2\u30fc\u30b7\u30e7\u30f3\u3068\u306e\u9593\u9694\u3092\u7a7a\u3051\u308b\u305f\u3081.section-content01\u3092\u524a\u9664 -->\r\n                    <div class=\"inner\">\r\n                        <ul class=\"c-flex c-col2\" id=\"anchor1\">\r\n                            <li>\r\n                                <h2 class=\"c-title -small -left\">\r\n                                    <span class=\"head\">VHH Antibody Contract Services<\/span>\r\n                                <\/h2>\r\n                            <\/li>\r\n                            <li>\r\n                                <h3 class=\"c-title2\">Launching a Joint Business to Support Drug Discovery and\r\n                                    Diagnostics Development<\/h3>\r\n                                <p class=\"c-text\">\r\n                                    VHH antibodies are single-domain antibodies which derive from the variable region of\r\n                                    the special heavy-chain antibodies possessed by camelids. Since the molecular weight\r\n                                    of VHH antibodies is about 1\/10 of that of conventional IgG antibodies, they can be\r\n                                    mass-produced with microorganisms at low cost. They are also highly resistant to\r\n                                    high temperature, denaturing agents, and changes in pH, making them suitable for use\r\n                                    in pharmaceuticals, diagnostics, and biosensors.\r\n                                    In 2023, we started a joint venture with RePHAGEN Co., Ltd., a start-up company from\r\n                                    the University of the Ryukyus. We provide one-stop contract services from screening\r\n                                    to manufacturing, by utilizing both RePHAGEN\u2019s proprietary VHH phage library and in\r\n                                    vitro evolution technology, and our cultural technology developed over many years.\r\n                                <\/p>\r\n                            <\/li>\r\n                        <\/ul>\r\n                        <ul class=\"c-block2 c-flex -center c-col\">\r\n                            <li>\r\n                                <div class=\"inner -middle\">\r\n                                    <div class=\"pic\"><img decoding=\"async\" src=\"\/assets\/img\/field\/bio-chemical\/vhh\/pic06_en.png\" alt=\"\">\r\n                                    <\/div>\r\n                                <\/div>\r\n                            <\/li>\r\n                        <\/ul>\r\n                    <\/div>\r\n                    <div class=\"inner\">\r\n                        <div class=\"c-block c-beforeBgColor -bgWhite\">\r\n                            <div class=\"contents-inner\">\r\n                                <div class=\"c-flex -center\">\r\n                                    <img decoding=\"async\" class=\"RePHAGEA-logo\"\r\n                                        src=\"\/assets\/img\/field\/bio-chemical\/vhh\/RePHAGEA-logo.png\" alt=\"\">\r\n                                <\/div>\r\n                                <ul class=\"c-block c-flex c-col2--half\">\r\n                                    <li>\r\n                                        <h3 class=\"c-title3\">Screening of VHH Antibodies<\/h3>\r\n                                        <p class=\"c-text\">Screening of VHH antibodies from the library with 40 billion\r\n                                            diversity\r\n                                        <\/p>\r\n                                    <\/li>\r\n                                    <li>\r\n                                        <div class=\"pic\">\r\n                                            <img decoding=\"async\" src=\"\/assets\/img\/field\/bio-chemical\/vhh\/pic01_en.png\" alt=\"\">\r\n                                        <\/div>\r\n                                    <\/li>\r\n                                <\/ul>\r\n                                <ul class=\"c-block c-flex c-col2--half\">\r\n                                    <li>\r\n                                        <h3 class=\"c-title3\">Improved Performance of Antibodies<\/h3>\r\n                                        <p class=\"c-text\">Development of antibodies with improved affinity, specificity,\r\n                                            and stability by in vitro evolution method.<\/p>\r\n                                        <p class=\"c-text\">CDR3 Preservation Method<br>\r\n                                            A library is constructed by randomly linking antigen-specific CDR3 region\r\n                                            genes to CDR1_2 region genes with 1 billion diversity, and then clones with\r\n                                            improved performance are selected.\r\n                                        <\/p>\r\n                                    <\/li>\r\n                                    <li>\r\n                                        <div class=\"pic\">\r\n                                            <img decoding=\"async\" src=\"\/assets\/img\/field\/bio-chemical\/vhh\/pic02_en.png\" alt=\"\">\r\n                                        <\/div>\r\n                                    <\/li>\r\n                                <\/ul>\r\n                            <\/div>\r\n                        <\/div>\r\n                    <\/div>\r\n                    <div class=\"inner\">\r\n                        <div class=\"c-block c-beforeBgColor -bgWhite\">\r\n                            <div class=\"contents-inner\">\r\n                                <div class=\"c-flex -center\">\r\n                                    <img decoding=\"async\" class=\"sanyofine-logo\"\r\n                                        src=\"\/assets\/img\/field\/bio-chemical\/vhh\/sanyofine-logo_en.png\" alt=\"\">\r\n                                <\/div>\r\n                                <div class=\"c-block\">\r\n                                    <h3 class=\"c-title3\">Process Development<\/h3>\r\n                                    <p class=\"c-text\">Cultivation of recombinant microorganisms (E. coli or yeast),\r\n                                        production of VHH antibodies, and optimization of purification conditions<\/p>\r\n                                    <ul class=\"c-block2 c-flex c-col2--half\">\r\n                                        <li>\r\n                                            <div class=\"pic\">\r\n                                                <img decoding=\"async\" src=\"\/assets\/img\/field\/bio-chemical\/pic01.png\" alt=\"\">\r\n                                            <\/div>\r\n                                        <\/li>\r\n                                        <li>\r\n                                            <div class=\"pic\">\r\n                                                <img decoding=\"async\" src=\"\/assets\/img\/field\/bio-chemical\/vhh\/pic04.png\" alt=\"\">\r\n                                            <\/div>\r\n                                        <\/li>\r\n                                    <\/ul>\r\n                                <\/div>\r\n                                <ul class=\"c-block c-flex c-col2--half\">\r\n                                    <li>\r\n                                        <h3 class=\"c-title3\">Scale-up Manufacturing<\/h3>\r\n                                        <p class=\"c-text\">\r\n                                            100 mL to 3000 L culture tank scale<br>\r\n                                            Harvest and sterilization (centrifuge, MF membrane)<br>\r\n                                            Bacteria disruption, column purification, ultrafiltration,\r\n                                            lyophilization<br>\r\n                                            In addition to VHH antibodies, we can also manufacture scFv, Fab, enzymes,\r\n                                            proteins, etc.<\/p>\r\n                                        <p class=\"c-text\">\r\n                                            GMP-compliant small-scale to mass-production facilities to be launched in\r\n                                            phases\r\n                                        <\/p>\r\n                                    <\/li>\r\n                                    <li>\r\n                                        <div class=\"pic\">\r\n                                            <img decoding=\"async\" src=\"\/assets\/img\/field\/bio-chemical\/vhh\/pic05.jpg\" alt=\"\">\r\n                                        <\/div>\r\n                                    <\/li>\r\n                                <\/ul>\r\n                            <\/div>\r\n                        <\/div>\r\n                    <\/div>\r\n                    <div class=\"c-section c-block c-beforeBgColor -bgBlue\">\r\n                        <div class=\"inner\">\r\n                            <ul class=\"c-flex c-col2\" id=\"anchor2\">\r\n                                <li>\r\n                                    <h2 class=\"c-title -small -left\">\r\n                                        <span class=\"head\">Sales of VHH Antibody Samples<\/span>\r\n                                    <\/h2>\r\n                                <\/li>\r\n                                <li>\r\n                                    <h3 class=\"c-title2\">Started Sales of Samples to Support Drug Discovery and\r\n                                        Diagnostics Development<\/h3>\r\n                                    <p class=\"c-text\">\r\n                                        We sell samples of monoclonal VHH antibodies screened and improved from\r\n                                        RePHAGEN&#8217;s proprietary VHH library.\r\n                                    <\/p>\r\n                                <\/li>\r\n                            <\/ul>\r\n                            <div class=\"c-block c-beforeBgColor -bgBlue-\">\r\n                                <h3 class=\"c-title3\">Product Information<\/h3>\r\n                                <div class=\"c-tableWrapSp js-scrollWrap\">\r\n                                    <div class=\"c-figScroll\"><img decoding=\"async\" src=\"\/assets\/img\/fig_scroll_en.png\" alt=\"\"><\/div>\r\n                                    <table class=\"c-table p-table01\">\r\n                                        <tr>\r\n                                            <th>Product Code<\/th>\r\n                                            <td>V10-1-1<\/td>\r\n                                            <td>V20-1-1<\/td>\r\n                                            <td>V30-1-1<\/td>\r\n                                            <td>V40-1-1<\/td>\r\n                                            <td>V50-1-1<\/td>\r\n                                        <\/tr>\r\n                                        <tr>\r\n                                            <th>Product Name<\/th>\r\n                                            <td>Anti-HSA VHH<\/td>\r\n                                            <td>Anti-cTnT VHH<\/td>\r\n                                            <td>Anti-Nectin-4 VHH<\/td>\r\n                                            <td>Anti-IL-6 VHH<\/td>\r\n                                            <td>Anti-HER2 VHH<\/td>\r\n                                        <\/tr>\r\n                                        <tr>\r\n                                            <th>Volume<\/th>\r\n                                            <td>100 \u03bcg<\/td>\r\n                                            <td>100 \u03bcg<\/td>\r\n                                            <td>100 \u03bcg<\/td>\r\n                                            <td>100 \u03bcg<\/td>\r\n                                            <td>100 \u03bcg<\/td>\r\n                                        <\/tr>\r\n                                        <tr>\r\n                                            <th>Price (excluding tax)<\/th>\r\n                                            <td>&yen;98,000<\/td>\r\n                                            <td>&yen;98,000<\/td>\r\n                                            <td>&yen;98,000<\/td>\r\n                                            <td>&yen;98,000<\/td>\r\n                                            <td>&yen;98,000<\/td>\r\n                                        <\/tr>\r\n                                    <\/table>\r\n                                <\/div>\r\n                                <p class=\"c-text\">\r\n                                    \u30fbSpecifications: Purity (HPLC) \u2267 95%, Concentration \u2267 1.0 mg\/mL<br>\r\n                                    \u30fbC-terminal is tagged with 3\u00d7DYKDDDDK tag and 6\u00d7His tag<br>\r\n                                    \u30fbFor research use only. <br>\r\n                                    \u30fbWe plan to gradually add more products.\r\n                                <\/p>\r\n                            <\/div>\r\n                        <\/div>\r\n                    <\/div>\r\n                    <ul class=\"c-flex -center -spB c-btnWrap--col2\">\r\n                        <li>\r\n                            <a href=\"\/en\/field\/bio-chemical\/\" data-target_tab_btn=\"tab_target1\"\r\n                                class=\"c-btn noScroll js-tabTrigger-otherBtn\">Biochemistry<\/a>\r\n                        <\/li>\r\n                        <li>\r\n                            <a href=\"\/en\/field\/\" class=\"c-btn\">The Business Fields<\/a>\r\n                        <\/li>\r\n                    <\/ul>\r\n                <\/div>\r\n\r\n            <\/main>\r\n","protected":false},"excerpt":{"rendered":"<p>HOME The Business Fields Biochemistry VHH Antibodies VHH Antibodies VHH Antibody Contract Services Sales of VH [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":87,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"http:\/\/www.sanyofine.co.jp\/?page_id=89","footnotes":""},"class_list":["post-91","page","type-page","status-publish","hentry","en-US"],"acf":[],"_links":{"self":[{"href":"http:\/\/www.sanyofine.co.jp\/wp-json\/wp\/v2\/pages\/91","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.sanyofine.co.jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.sanyofine.co.jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.sanyofine.co.jp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.sanyofine.co.jp\/wp-json\/wp\/v2\/comments?post=91"}],"version-history":[{"count":5,"href":"http:\/\/www.sanyofine.co.jp\/wp-json\/wp\/v2\/pages\/91\/revisions"}],"predecessor-version":[{"id":361,"href":"http:\/\/www.sanyofine.co.jp\/wp-json\/wp\/v2\/pages\/91\/revisions\/361"}],"up":[{"embeddable":true,"href":"http:\/\/www.sanyofine.co.jp\/wp-json\/wp\/v2\/pages\/87"}],"wp:attachment":[{"href":"http:\/\/www.sanyofine.co.jp\/wp-json\/wp\/v2\/media?parent=91"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}